Anti-CYCS monoclonal antibody, clone 48CB22 [Alexa Fluor® 488]

Antibody Isotype

IgG2a

Clone

48CB22

Species Reactivity

Mouse; Rat; Cow; Human; C. elegans

Immunogen

Bovine heart Cytochrome C.

Conjugate

Application Notes

Flow Cyt: 0.2 μg/ml; ICC/IF: 1 μg/ml.

Alternative Names

CYCS; cytochrome c, somatic; cytochrome c; MGC128356;

Entrez Gene ID

UniProt ID

Antigen Description

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Pathway

Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem;