Anti-CYCS monoclonal antibody, clone 3C6.G9

Antibody Isotype

IgG2a

Clone

3C6.G9

Species Reactivity

Horse

Immunogen

Native Horse Cytochrome C.

Conjugate

Alternative Names

CYCS; cytochrome c, somatic; cytochrome c;

Entrez Gene ID

UniProt ID

Antigen Description

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Pathway

Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Colorectal cancer, organism-specific biosystem;