Anti-TNFRSF1A monoclonal antibody, clone 66S-397

Antibody Isotype

IgG

Clone

66S-397

Species Reactivity

Mouse

Conjugate

Application Notes

Flow Cytometric: 1.0 μg/10⁶ cells

Alternative Names

CXCR1; chemokine (C-X-C motif) receptor 1; C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; IL-8R A; CXC chemokine receptor 1; interleukin9receptor, alpha; high affinity interleukin-8 receptor A; Il8ra;

Entrez Gene ID

UniProt ID

Antigen Description

Tumor Necrosis Factor Receptor Type I (TNFRI); is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-alpha and TNF-beta; (also known as LT-alpha );. The subsequent signaling is known to be important for inducing cytolytic activity, antiviral activity, expression of manganous superoxide dismutase and intercellular adhesion molecule (ICAM);, IL-6 mRNA accumulation and NF-?B induction. TNFRI carries an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein);. Binding of66S-280antibody to TNFRI has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.

Pathway

Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endocytosis, organism-specific biosystem;