This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
Pathway
AKT phosphorylates targets in the nucleus; ATM Signaling Pathway; Activation of NMDA receptor upon glutamate binding and postsynaptic events; Adipogenesis
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