Anti-CREB1 monoclonal antibody, clone MC0 Knockout Validated

Name: Anti-CREB1 monoclonal antibody, clone MC0
SKU: DCABH-6460

Mouse anti-Human CREB1 monoclonal antibody for ICC/IF, WB, IP, IHC-P, ELISA

Write a review

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG1

Clone

MC0

Species Reactivity

Mouse; Rat; Human; African green monkey

Immunogen

Recombinant full length protein corresponding to Human CREB aa 1-341.Sequence: MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT QISTIAESED SQESVDSVTD SQKRREILSR RPSYRKILND LSSDAPGVPR IEEEKSEEET

Conjugate

Unconjugated

Applications

Application Notes

ICC/IF: 1/500; WB: 1/500; IHC-P: 1/200; ELISA: 0.1 - 1 μg/ml.

Target

Alternative Names

CREB1; cAMP responsive element binding protein 1; cyclic AMP-responsive element-binding protein 1; CREB-1; transactivator protein; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB;

Entrez Gene ID

1385

UniProt ID

P16220

Product Background

Antigen Description

This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.

Pathway

AKT phosphorylates targets in the nucleus, organism-specific biosystem; ATF-2 transcription factor network, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Amphetamine addiction, organism-specific biosystem;

Citations