Anti-CPT1A monoclonal antibody, clone 9G7BF0 [Alexa Fluor® 488]

Antibody Isotype

IgG2b

Clone

9G7BF0

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment corresponding to Human CPT1A aa 489-773 (C terminal).Sequence: MSIDSLQLGYAEDGHCKGDINPNIPYPTRLQWDIPGECQEVIETSLNTAN LLANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQLAHYKDMGKFCLT YEASMTRLFREGRTETVRSCTTESCDFVRAMVDPAQTVEQRLKLFKLASE KHQHMYRLAMTGSGIDRH

Conjugate

Application Notes

ICC/IF: 5 μg/ml; Flow Cyt: 5 μg/ml.

Alternative Names

CPT1A; carnitine palmitoyltransferase 1A (liver); CPT1; carnitine O-palmitoyltransferase 1, liver isoform; CPT1 L; L CPT1; CPT I; CPTI-L; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform; CPT1-L; L-CPT1;

Entrez Gene ID

UniProt ID

Antigen Description

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Pathway

AMPK signaling, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Circadian Clock, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Fatty Acid Beta Oxidation, organism-specific biosystem; Fatty acid metabolism, organism-specific biosystem;