Anti-CPT1A monoclonal antibody, clone 9G7BF0 Knockout Validated

Antibody Isotype

IgG2b

Clone

9G7BF0

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment, corresponding to amino acids 489-773 of Human CPT1A.

Conjugate

Application Notes

IHC-P: 0.5 μg/ml; WB: 1 μg/ml; ICC/IF: 0.5 - 5 μg/ml; In-Cell ELISA: 0.1 - 1 μg/ml.

Alternative Names

CPT1A; carnitine palmitoyltransferase 1A (liver); CPT1; carnitine O-palmitoyltransferase 1, liver isoform; CPT1 L; L CPT1; CPT I; CPTI-L; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform; CPT1-L; L-CPT1;

Entrez Gene ID

UniProt ID

Antigen Description

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Pathway

AMPK signaling, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Circadian Clock, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Fatty Acid Beta Oxidation, organism-specific biosystem; Fatty acid metabolism, organism-specific biosystem;