Anti-CPEB1 (aa 446-475) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 446-475 of Human CPEB1 (NP_001073001.1, NP_001073002.1).

Conjugate

Application Notes

WB: 1/100 - 1/500.

Alternative Names

CPEB1; cytoplasmic polyadenylation element binding protein 1; cytoplasmic polyadenylation element-binding protein 1; CPEB; FLJ13203; h-CEBP; hCPEB-1; CPE-binding protein 1; CEBP; CPE-BP1; MGC34136; MGC60106;

Entrez Gene ID

UniProt ID

Antigen Description

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.

Pathway

Aurora A signaling; Dorso-ventral axis formation; Oocyte meiosis; Progesterone-mediated oocyte maturation;