Anti-CPEB1 monoclonal antibody, clone FQS22886(3)

Antibody Isotype

IgG

Clone

FQS22886(3)

Species Reactivity

Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human CPEB1 aa 250-350. The exact sequence is proprietary.Database link: Q9BZB8

Conjugate

Application Notes

WB: 1/1000 - 1/2000; IP: 1/60;

Alternative Names

CPEB1; cytoplasmic polyadenylation element binding protein 1; cytoplasmic polyadenylation element-binding protein 1; CPEB; FLJ13203; h-CEBP; hCPEB-1; CPE-binding protein 1; CEBP; CPE-BP1; MGC34136; MGC60106;

Entrez Gene ID

UniProt ID

Antigen Description

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.

Pathway

Aurora A signaling, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem; Oocyte meiosis, organism-specific biosystem; Oocyte meiosis, conserved biosystem; Progesterone-mediated oocyte maturation, organism-specific biosystem; Progesterone-mediated oocyte maturation, conserved biosystem;