Anti-COL11A2 (aa 29-128) polyclonal antibody

Species Reactivity

Human

Immunogen

COL11A2 (NP_542411, 29 a.a. ~ 128 a.a) partial recombinant protein with GST tag. The sequence is APPVDVLRALRFPSLPDGVRRAKGICPADVAYRVARPAQLSAPTRQLFPGGFPKDFSLLT VVRTRPGLQAPLLTLYSAQGVRQLGLELGRPVRFLYEDQT

Conjugate

Alternative Names

COL11A2; collagen, type XI, alpha 2; HKE5; PARP; STL3; FBCG2; DFNA13; DFNB53; collagen alpha-2(XI) chain; pro-a2 chain of collagen type XI;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.

Pathway

Amoebiasis; Collagen biosynthesis and modifying enzymes; ECM-receptor interaction; Focal Adhesion