Anti-CNGA3 (aa 1-100) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human CNG3.

Conjugate

Application Notes

WB: 1 μg/ml;

Alternative Names

CNGA3; cyclic nucleotide gated channel alpha 3; CNG3; ACHM2; CCNC1; CCNCa; CNCG3; CCNCalpha; cyclic nucleotide-gated cation channel alpha-3; CNG-3; CNG channel alpha-3; cyclic nucleotide-gated channel alpha-3; cone photoreceptor cGMP-gated channel alpha s

Entrez Gene ID

UniProt ID

Antigen Description

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.

Pathway

Olfactory transduction; Visual signal transduction: Cones;