Anti-CHRM3 monoclonal antibody (DCABH-11010) Made to order

Rabbit anti-Human CHRM3 monoclonal antibody for WB, ELISA

View other CHRM3 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CHRM3 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CHRM3; cholinergic receptor, muscarinic 3; muscarinic acetylcholine receptor M3; acetylcholine receptor; muscarinic 3; m3 muscarinic receptor
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CHRM3 (Cholinergic Receptor Muscarinic 3) is a Protein Coding gene. Diseases associated with CHRM3 include prune belly syndrome and low compliance bladder. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include G-protein coupled receptor activity and drug binding. An important paralog of this gene is CHRM4. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.
Antigen Description
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Prune belly syndrome (PBS) [MIM:100100]: A syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry. The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3. 0The function about CHRM3 antigen include G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; acetylcholine binding; drug binding; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity.
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Kalantari-Dehaghi, M; Anhalt, GJ; et al. Pemphigus Vulgaris Autoantibody Profiling by Proteomic Technique. PLOS ONE 8:-(2013).
Belo, A; Cheng, KR; et al. Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 300:G749-G760(2011).

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