Magic™ Anti-CFP monoclonal antibody, clone N92403

The present investigation aimed at comparing the efficacy of two packing materials (LDPE and CFB boxes) and two storage conditions (cold storage and ambient conditions) in retaining the quality of stored aonla fruits. Under cold storage the fruits were subjected to different temperatures viz 6 degrees C, 9 degrees C and 12 degrees C with 90-95% RH, whereas for ambient conditions the fruits were kept at room temperature (18 +/- 1 degrees C). Periodically a representative sample of the stored fruits was taken out and analyzed for changes in physico-chemical attributes. The results revealed that LDPE bags significantly retained the quality of stored fruits in terms of PLW, spoilage, ascorbic acid and total phenols. LDPE packed fruits stored at 9 degrees C registered minimum PLW followed by CFB boxes and it increased concomitantly with the storage interval. Total phenols and TSS registered an increasing trend initially but gradually declined thereafter. In general the aonla fruits showed increased PLW and decreased firmness, TSS, acidity and ascorbic acid as the storage interval was increased. Chilling injury was observed in fruits stored at 6 degrees C only. The storage temperature, packing material and storage interval had significant influence on ascorbic acid and of the fruits. The present study implies that the aonla fruits can be efficiently stored in LDPE packaging at temperature of 9 degrees C for 21 days.

Gain-of-function variants in CFB encoding factor B (FB), a component of the alternative pathway C3 convertase, have been reported in a minority of patients with aHUS and result in massive C3 activation. Zhang et al. describe the functional characterization of a novel FB variant (p.Ser367Arg) that they identified in 2 unrelated aHUS pedigrees who had undetectable C3 levels. The mutant FB caused strong C3 cleavage in fluid-phase but also C3 deposition on cell surface. This commentary addresses the implications of these findings for understanding the complexity of complement-related genetic renal diseases. Copyright (C) 2020, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.