CDC6 (NP_001245, 434 a.a. ~ 533 a.a) partial recombinant protein with GST tag. The sequence is ISQVISEVDGNRMTLSQEGAQDSFPLQQKILVCSLMLLIRQLKIKEVTLGKLYEAYSKVC RKQQVAAVDQSECLSLSGLLEARGILGLKRNKETRLTKVF
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
Pathway
Activation of ATR in response to replication stress; Assembly of the pre-replicative complex; CDC6 association with the ORC:origin complex; CDT1 association with the CDC6:ORC:origin complex
Citations
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