Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Pathway
Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Association of licensing factors with the pre-replicative complex; CDC6 association with the ORC:origin complex; CDK-m
Citations
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