Specifications
Immunogen
Synthetic peptide (Human) (13 C terminal amino acids of the cytoplasmic domain).
Applications
Application Notes
Flow Cyt: 1/100; IHC-P: 1/25 - 1/50.
Target
Alternative Names
CD8A; CD8a molecule; CD8, CD8 antigen, alpha polypeptide (p32) , T cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte
Product Background
Antigen Description
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem;
Citations
Publication ()
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COA
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