Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human CBX2 aa 450 to the C-terminus. The exact sequence is proprietary.Database link: Q14781
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/10000 - 1/50000; Flow Cyt: 1/220;
Target
Alternative Names
CBX2; chromobox homolog 2 (Pc class homolog, Drosophila); CDCA6, cell division cycle associated 6 , chromobox homolog 2 (Drosophila Pc class); MGC10561; Pc class homolog (Drosophila); M33; CDCA6;
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
Citations
Publication ()
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COA
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