General Notes
This product (Catalog No. DPABH-16578) is a rabbit-derived polyclonal antibody raised against human CANX, targeting the amino acid region 21–481 of the protein. This antibody exhibits cross-reactivity with Human CANX from mouse and rat. It has been affinity purified by Protein A. alnexin is a type I integral membrane protein primarily localized to the endoplasmic reticulum (ER), where it functions as a lectin-like molecular chaperone essential for the folding, assembly, and quality control of N-linked glycoproteins entering the secretory pathway. As a key component of the ER protein folding machinery, it binds transiently to monoglucosylated oligosaccharides on nascent polypeptides, preventing aggregation and promoting proper conformational maturation while facilitating the retention of misfolded proteins for degradation. This process is integral to cellular homeostasis, with calnexin deficiencies implicated in neurological disorders, developmental defects, and disruptions in immune responses such as MHC class I biogenesis.
DPABH-16578 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-16578 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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