Anti-CACNA1S monoclonal antibody, clone nBC 2b

Antibody Isotype

IgG1

Clone

nBC 2b

Immunogen

purified t-tubules

Conjugate

Alternative Names

CACNA1S; calcium channel, voltage-dependent, L type, alpha 1S subunit; CACNL1A3, HOKPP, MHS5; voltage-dependent L-type calcium channel subunit alpha-1S; Cav1.1; hypoPP; dihydropyridine receptor; voltage-gated calcium channel subunit alpha Cav1.1; dihydrop

Entrez Gene ID

UniProt ID

Antigen Description

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the high-voltage activated (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.

Pathway

Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Axon guidance, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem;