Anti-CACNA1S monoclonal antibody, clone 2B

Antibody Isotype

IgG1

Clone

2B

Species Reactivity

Mouse; Rat; Rabbit; Guinea pig; Human

Immunogen

Full length native protein (purified) corresponding to Rabbit CACNA1S. Purified from rabbit muscle T-tubule dihydropyridine receptor.

Conjugate

Application Notes

IHC-Fr: 1/200; WB: 1/500; IHC-P: 1/20.

Alternative Names

CACNA1S; calcium channel, voltage-dependent, L type, alpha 1S subunit; voltage-dependent L-type calcium channel subunit alpha-1S; voltage-gated calcium channel subunit alpha Cav1.1; calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle;

Entrez Gene ID

UniProt ID

Antigen Description

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the high-voltage activated (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.