Anti-CABIN1 (aa 1-110) polyclonal antibody

Species Reactivity

Human

Immunogen

CABIN1 (NP_036427, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. The sequence is MIRIAALNASSTIEDDHEGSFKSHKTQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYH ELLEASLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQREDLETAM

Conjugate

Alternative Names

CABIN1; calcineurin binding protein 1; CAIN; PPP3IN; calcineurin-binding protein cabin-1; calcineurin inhibitor; calcineurin binding protein cabin 1;

Entrez Gene ID

UniProt ID

Antigen Description

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.

Pathway

Calcium signaling in the CD4+ TCR pathway; Cellular responses to stress; Formation of Senescence-Associated Heterochromatin Foci (SAHF);