Anti-CABIN1 monoclonal antibody, clone 3G6

Antibody Isotype

IgG2a

Clone

3G6

Species Reactivity

Human

Immunogen

CABIN1 (NP_036427, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

CABIN1; calcineurin binding protein 1; calcineurin-binding protein cabin-1; KIAA0330; PPP3IN; calcineurin inhibitor; calcineurin binding protein cabin 1; CAIN;

Entrez Gene ID

UniProt ID

Antigen Description

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.

Pathway

Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem;