Synthetic peptide corresponding to a region within internal sequence amino acids 540-589 (GVFRKFATDN NCHVTLVIHP RKEDDDKELQ TASIFGSAKA SQEADNVLIL) of human Twinkle (NP_068602).
Conjugate
Unconjugated
Applications
Application Notes
ICC/IF: 1 μg/ml; WB: 1 μg/ml; Titer in peptide based assay: 1/312500;
Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.
Pathway
Mitochondrial biogenesis; Transcriptional activation of mitochondrial biogenesis;
Citations
Publication ()
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