Synthetic peptide corresponding to a region within the internal sequence amino acids 612-661 (GDVGVFPLEF NKNSLTFSIP PKNKARLKKI KDDTGPVAKK PSSGKKGATT) of Human Twinkle (NP_068602)
Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.
Pathway
Mitochondrial biogenesis; Transcriptional activation of mitochondrial biogenesis;
Citations
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