Anti-S-100 monoclonal antibody (DMAB5483MB)

Mouse anti-Bovine S-100 monoclonal antibody for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
5D5.0
Species Reactivity
Bovine
Immunogen
BALB/C mice were immunized with purified bovine brain S-100 protein.
Conjugate
Unconjugated

Target


Alternative Names
S100B; S100 calcium binding protein B; protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100-B
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
S-100 protein is a family of low molecular weight protein found in vertebrates characterized by two calcium binding sites of the helix-loop-helix ("EF-hand type") conformation. There are at least 21 different types of S100 proteins. The name is derived from the fact that the protein is 100% Soluble in ammonium sulfate at neutral pH. The function about S-100 antigen include RAGE receptor binding; S100 beta binding; calcium ion binding; calcium-dependent protein binding; kinase inhibitor activity; protein binding; protein homodimerization activity; tau protein binding; zinc ion binding.
Pathway
Activated TLR4 signalling; Immune System; Innate Immune System; MyD88 cascade initiated on plasma membrane; MyD88 dependent cascade initiated on endosome; MyD88-independent cascade initiated on plasma membrane; MyD88:Mal cascade initiated on plasma membra.

Citations


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References


Romano, LA; Klosterhoff, M; et al. Multiple neurofibromas of the heart in wild carp, Cyprinus carpio: optical, immunohistochemical and ultrastructural study. BULLETIN OF THE EUROPEAN ASSOCIATION OF FISH PATHOLOGISTS 35:1-7(2015).
Kluft, C; van Leuven, CJM; et al. Consequences for the APTT due to direct action of factor XIa on factor X, resulting in bypassing factors VIII-IX. THROMBOSIS RESEARCH 135:198-204(2015).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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