Anti-BMPR1A (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

BMPR1A (AAH28383, 1 a.a. ~ 532 a.a) full-length recombinant protein with GST tag. The sequence is MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSGFQCKDSPKAQLRR TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC KSISSRRRYNRDLEQDEAFIPVGESLKDLVDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRV

Conjugate

Alternative Names

BMPR1A; bone morphogenetic protein receptor, type IA; ALK3; SKR5; CD292; ACVRLK3; 10q23del; bone morphogenetic protein receptor type-1A; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serin

Entrez Gene ID

UniProt ID

Antigen Description

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Pathway

BMP signalling and regulation; Cytokine-cytokine receptor interaction; Heart Development; Hippo signaling pathway