Specifications
Immunogen
Purified recombinant fragment, corresponding to amino acids 179-378 of Human BMPR1A, expressed in E. coli (Uniprot: P36894).
Applications
Application Notes
WB: 1/500 - 1/2000; IHC-P: 1/200 - 1/1000; Flow Cyt: 1/200 - 1/400;
Target
Alternative Names
BMPR1A; bone morphogenetic protein receptor, type IA; ACVRLK3; bone morphogenetic protein receptor type-1A; ALK3; CD292; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serine/threonine-prot
Product Background
Antigen Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.
Pathway
Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; Heart Development, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by BMP, organism-specific biosystem; TGF-beta signaling pathway, organism-specific biosystem;
Citations
Publication ()
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COA
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