Anti-BMPR1A monoclonal antibody, clone 5D5

Antibody Isotype

IgG2a

Clone

5D5

Species Reactivity

Human

Immunogen

BMPR1A (AAH28383, 1 a.a. ~ 533 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

bone morphogenetic protein receptor, type IA; BMP type-1A receptor; ALK3; EC 2.7.11.30; ACVRLK3; 10q23del; CD292; OTTHUMP00000020014; Activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; Serine/threonine-protein kinase receptor R5; b

Entrez Gene ID

UniProt ID

Antigen Description

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
Mouse monoclonal antibody raised against a full-length recombinant BMPR1A.

Pathway

Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; Heart Development, organism-specific biosystem; Signaling by BMP, organism-specific biosystem; TGF-beta signaling pathway, organism-specific biosystem