Synthetic peptide corresponding to a region between residues 175 and 225 of Human HSPC142 (NP_054892.2)
Conjugate
Unconjugated
Target
Alternative Names
BABAM1; BRISC and BRCA1 A complex member 1; NBA1; HSPC142; MERIT40; C19orf62; BRISC and BRCA1-A complex member 1; BRCA1-A complex subunit MERIT40; new component of the BRCA1 A complex; new component of the BRCA1-A complex; new component of the BRCAA1 A co
Component of the BRCA1-A complex, a complex that specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the Lys-63-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Ambivero, CT; Cilenti, L; et al. ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1823:2149-2156(2012).
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COA
Certificate of Analysis