Anti-BABAM1 monoclonal antibody, clone HU3921

Antibody Isotype

IgG2b

Clone

HU3921

Species Reactivity

Human

Immunogen

Recombinant fragment within Human HSPC142 aa 1-130. The exact sequence is proprietary.Sequence: MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSE GEGEAASADDGSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLD LSEEMSLPKLESFNGSKTNALNVSQKMIEM Database link: Q9NWV8

Conjugate

Application Notes

ICC/IF: 1/100 - 1/1000; WB: 1/500 - 1/3000.

Alternative Names

BABAM1; BRISC and BRCA1 A complex member 1; C19orf62, chromosome 19 open reading frame 62; BRISC and BRCA1-A complex member 1; FLJ20571; HSPC142; Mediator of Rap80 Interactions and Targeting 40 kD; MERIT40; NBA1; new component of the BRCA1 A complex; BRC

Entrez Gene ID

UniProt ID

Antigen Description

Component of the BRCA1-A complex, a complex that specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the Lys-63-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.