Anti-BABAM1 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human C19orf62 is used for rabbit immunization.

Conjugate

Alternative Names

BABAM1; BRISC and BRCA1 A complex member 1; NBA1; HSPC142; MERIT40; C19orf62; BRISC and BRCA1-A complex member 1; BRCA1-A complex subunit MERIT40; new component of the BRCA1 A complex; new component of the BRCA1-A complex; new component of the BRCAA1 A co

Entrez Gene ID

UniProt ID

Antigen Description

BRCA1-A complex subunit MERIT40 is a protein that in humans is encoded by the C19orf62 gene. BABAM1 (BRISC and BRCA1 A complex member 1) is a protein-coding gene. Diseases associated with BABAM1 include ovarian cancer, and breast cancer, and among its related super-pathways are Cell Cycle / Checkpoint Control. GO annotations related to this gene include protein binding. An important paralog of this gene is ENSG00000269307. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component.