Anti-ATP2A2 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human ATP2A2 is used for rabbit immunization.

Conjugate

Alternative Names

ATP2A2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; DD; DAR; ATP2B; SERCA2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; calcium pump 2; SR Ca(2+)-ATPase 2; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; ATPase,

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

Pathway

Adrenergic signaling in cardiomyocytes; Adrenergic signaling in cardiomyocytes; Alzheimers disease; Arrhythmogenic right ventricular cardiomyopathy; Calcium Regulation in the Cardiac Cell; Calcium signaling pathway;Cardiac muscle contraction; Dilated cardiomyopathy; Endothelin; Hemostasis; Hypertrophic cardiomyopathy (HCM);