Rabbit Anti-Human ATL1 (a.a. 449-558) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Rat; Pig

Immunogen

Recombinant human ATL1 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 449-558 aa of BC010708

Conjugate

Application Notes

WB: 1:1000-1:4000

General Notes

This product (Catalog No. DPABH-12168) is a rabbit-derived polyclonal antibody raised against human ATL1, targeting the amino acid region 449–558 of the protein. This antibody exhibits cross-reactivity with Human ATL1 from rat and pig. It has been affinity purified by Protein A. ATL1 encodes atlastin-1, a GTPase that plays a crucial role in maintaining the structure and function of the endoplasmic reticulum. Mutations in ATL1 are one of the most common causes of hereditary spastic paraplegia (HSP) (PMID: 38851544). tlastin-1 is regulated by ubiquitination, a post-translational modification that can affect its activity and localization. For example, the E3 ubiquitin ligase SYVN1 has been shown to ubiquitinate atlastin-1, inhibiting its GTPase activity and thereby affecting ER morphology (PMID: 32916628).
DPABH-12168 is suitable for use in Western blot (WB) (1:1,000–1:4,000) application.
DPABH-12168 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Brain-specific GTP-binding protein; Atlastin-1; atlastin1; atlastin GTPase 1; Atlastin 1

Entrez Gene ID

UniProt ID