Anti-ATL1 monoclonal antibody, clone 2C0

Antibody Isotype

IgG1

Clone

2C0

Species Reactivity

Human; Rat

Immunogen

SPG3A (NP_056999, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

ATL1; atlastin GTPase 1; spastic paraplegia 3A (autosomal dominant) , SPG3, SPG3A; atlastin-1; AD FSP; atlastin; FSP1; GBP-3; hGBP3; GTP-binding protein 3; guanylate-binding protein 3; spastic paraplegia 3 protein A; brain-specific GTP-binding protein; gu

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.