Anti-ATG5 monoclonal antibody, clone FQS5808 Knockout Validated

Antibody Isotype

IgG

Clone

FQS5808

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues near the N-terminus of Human APG5L/ATG5.

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250; ICC: 1/100 - 1/250.

Alternative Names

ATG5; ATG5 autophagy related 5 homolog (S. cerevisiae); APG5 (autophagy 5, S. cerevisiae) like , APG5 autophagy 5 like (S. cerevisiae) , APG5L; autophagy protein 5; APG5; ASP; hAPG5; apoptosis specific protein; apoptosis-specific protein; APG5L; APG5-LIK

Entrez Gene ID

UniProt ID

Antigen Description

Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed.May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.

Pathway

Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem; RIG-I-like receptor signaling pathway, organism-specific biosystem; RIG-I-like receptor signaling pathway, conserved biosystem; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem; Regulation of autophagy, organism-specific biosystem;