Anti-ARL6 monoclonal antibody (DCABH-10611) Made to order

Rabbit anti-Human ARL6 monoclonal antibody for WB, ELISA

View other ARL6 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ARL6 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ARL6; ADP-ribosylation factor-like 6
Entrez Gene ID

Product Background


Gene summary
ARL6 (ADP Ribosylation Factor Like GTPase 6) is a Protein Coding gene. Diseases associated with ARL6 include retinitis pigmentosa 55 and bardet-biedl syndrome 3. Among its related pathways are Organelle biogenesis and maintenance and Cargo trafficking to the periciliary membrane. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL1. The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). A vision-specific transcript, encoding long isoform BBS3L, has been described (PMID: 20333246).
Antigen Description
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described. Bardet-Biedl syndrome 3 (BBS3) [MIM:600151]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. Note=The disease is caused by mutations affecting the gene represented in this entry. Retinitis pigmentosa 55 (RP55) [MIM:613575]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Tu, CT; Yang, TC; et al. Zebrafish arl6ip1 Is Required for Neural Crest Development during Embryogenesis. PLOS ONE 7:-(2012).
Muromoto, R; Sekine, Y; et al. BART is essential for nuclear retention of STAT3. INTERNATIONAL IMMUNOLOGY 20:395-403(2008).

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