Recombinant full length protein corresponding to Human ARL6 aa 2-186.Sequence: GLLDRLSVLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTI GFSIEKFKSSSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLR MVVAKEELDTLLNHPDIKHRRIPILFFANKMDLRDAVTSVKVSQLLCLEN IKDKPWHICASDAIKGEGLQEGV
Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization.
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