Synthesized peptide derived from internal of human ARHGEF9.
Conjugate
Unconjugated
Applications
Application Notes
IHC: 1:50-1:100
General Notes
This product (Catalog No. DPABH-02184) is a rabbit-derived IgG polyclonal antibody raised against human ARHGEF9. It has been affinity purified by protein A. The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. This brain-specific protein also acts as an adaptor protein for the recruitment of gephyrin and together these proteins facilitate receceptor recruitement in GABAnergic and glycinergic synapses. Defects in this gene are the cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy, as well as several other types of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. DPABH-02184 is suitable for use in IHC (1:50–1:100) application. DPABH-02184 is supplied as a liquid formulation in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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