Anti-ARHGEF9 monoclonal antibody, clone 4D22

Antibody Isotype

IgG2a

Clone

4D22

Species Reactivity

Human

Immunogen

ARHGEF9 (NP_056000.1, 419 a.a. ~ 516 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

ARHGEF9; Cdc42 guanine nucleotide exchange factor (GEF) 9; rho guanine nucleotide exchange factor 9; collybistin; KIAA0424; PEM 2; PEM-2 homolog; hPEM-2 collybistin; rac/Cdc42 guanine nucleotide exchange factor 9; PEM2; EIEE8; PEM-2; HPEM-2; COLLYBISTIN;

Entrez Gene ID

UniProt ID

Antigen Description

ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.

Pathway

Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; GABA A receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Ion channel transport, organism-specific biosystem; Ligand-gated ion channel transport, organism-specific biosystem;