Synthetic peptide: C-PDFSSQKLQH with a Cysteine residue linker, corresponding to internal sequence amino acids 76-85 of Human Angiopoietin 1 (NP_001137.2).
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
Pathway
Angiogenesis; Cell surface interactions at the vascular wall; Hemostasis; PI3K-Akt signaling pathway
Citations
Publication ()
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