Mouse ANGPT1 blocking peptide (CDBP0396)

Synthetic Mouse ANGPT1 blocking peptide for BL

Product Overview
Angiopoietin - 1 ( N - term ) peptide ( mouse )
Target
Angiopoietin 1
Nature
Synthetic
Species Reactivity
Mouse
Tag/Conjugate
Unconjugated
Procedure
None
Concentration
1 mg/ml
Size
50 μg
Buffer
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% sodium azide
Preservative
0.01% Sodium Azide
Storage
Upon Receipt - Keep as concentrated solution. Aliquot and store at -20℃ or below. Avoid freeze-thaw cycles.
UniProt ID
Antigen Description
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
Function
receptor tyrosine kinase binding;
Synonyms
ANGPT1; angiopoietin 1; AGP1; AGPT; ANG1; angiopoietin-1; ANG-1;

Citations


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References


Daly, C; Eichten, A; et al. Angiopoietin-2 Functions as a Tie2 Agonist in Tumor Models, Where It Limits the Effects of VEGF Inhibition. CANCER RESEARCH 73:108-118(2013).
Parborell, F; Abramovich, D; et al. Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes. BIOLOGY OF REPRODUCTION 78:506-513(2008).

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