Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Angiopoietin 1 aa 350-450. The exact sequence is proprietary.Database link: Q15389
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
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