General Notes
This product (Catalog No. DPABH-12777) is a rabbit-derived polyclonal antibody raised against human AGXT, targeting the amino acid region 1–392 of the protein. It has been affinity purified by Protein A. AGXT (alanine–glyoxylate aminotransferase) encodes a peroxisomal enzyme that catalyzes the transamination between alanine and glyoxylate to form pyruvate and glycine, playing a critical role in glyoxylate detoxification. AGXT is primarily expressed in the liver and functions to prevent the accumulation of glyoxylate, which can otherwise be converted into oxalate, a major component of kidney stones. The enzyme requires pyridoxal 5′-phosphate (vitamin B6) as a cofactor for catalytic activity. Deficiency or dysfunction of AGXT is associated with primary hyperoxaluria type 1, a rare autosomal recessive metabolic disorder characterized by excessive oxalate production, recurrent nephrolithiasis, and potential systemic oxalosis leading to renal failure. Proper AGXT function is therefore essential for maintaining glyoxylate and oxalate metabolic balance.
DPABH-12777 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-12777 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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