Anti-AGXT monoclonal antibody, clone FQS24343-60

Antibody Isotype

IgG

Clone

FQS24343-60

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment within Human AGXT. The exact sequence is proprietary.Database link: P21549

Conjugate

Application Notes

IHC-P: 1/100 - 1/250; WB: 1/1000 - 1/10000; Flow Cyt: 1/10 - 1/100.

Alternative Names

AGXT; alanine-glyoxylate aminotransferase; SPAT; serine--pyruvate aminotransferase; AGT; AGT1; AGXT1; glycolicaciduria; L alanine: glyoxylate aminotransferase 1; oxalosis I; PH1; primary hyperoxaluria type 1; serine:pyruvate aminotransferase; SPT; serine-

Entrez Gene ID

UniProt ID

Antigen Description

This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria.

Pathway

Alanine and aspartate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Glycine, serine and threonine metabolism, organism-specific biosystem; Glycine, serine and threonine metabolism, conserved biosystem; Glyoxylate and dicarboxylate metabolism, organism-specific biosystem; Glyoxylate and dicarboxylate metabolism, conserved biosystem;