General Notes
This product (Catalog No. DPABH-02403) is a rabbit-derived polyclonal antibody raised against human ADRA2C, targeting the amino acid region 232–379 of the protein. It has been affinity purified by Protein A. ADRA2C (alpha-2C adrenergic receptor) encodes a G protein–coupled receptor that belongs to the α2-adrenergic receptor family and is primarily coupled to Gi/o proteins. Activation of the alpha-2C adrenergic receptor inhibits adenylate cyclase activity, leading to reduced intracellular cyclic AMP levels and modulation of neurotransmitter release. This receptor is expressed in the central nervous system, cardiovascular system, and peripheral tissues, where it participates in regulating sympathetic nervous system activity, vascular tone, and neurotransmission. The alpha-2C adrenergic receptor has been implicated in stress response, thermoregulation, and neuropsychiatric and cardiovascular physiology. Genetic polymorphisms or altered expression of ADRA2C have been associated with variations in autonomic function and disease susceptibility.
DPABH-02403 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-02403 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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