The alpha 2C Adrenergic Receptor controls the release of neurotransmitter from central adrenergic neurons and from sympathetic nerves in the heart. This receptor also plays a role in cognitive and behavioral function. Two variants are produced by alternative splicing. Alpha 2C Adrenergic Receptor has been reported extensively in the brain. Blood, corpus cavermosum, kidney, and heart tissues have also been reported to express the protein.
Pathway
Adrenaline signalling through Alpha-2 adrenergic receptor; Adrenoceptors; Class A/1 (Rhodopsin-like receptors); G alpha (z) signalling events
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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REMAURY, A; PARIS, H; et al. THE INSULIN-SECRETING CELL-LINE, RINM5F, EXPRESSES AN ALPHA-2D ADRENOCEPTOR AND NONADRENERGIC IDAZOXAN-BINDING SITES. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 260:417-426(1992).
Kingery, WS; Agashe, GS; et al. Isoflurane and nociception - Spinal alpha(2A) adrenoceptors mediate antinociception while supraspinal alpha(1) adrenoceptors mediate pronociception. ANESTHESIOLOGY 96:367-374(2002).
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COA
Certificate of Analysis
