Specifications
Immunogen
Synthetic peptide: ESNYCLKNDV SNPQGTLQDG TSRFTCRRKP IHHFLGISTF SQYTVVDENA, corresponding to amino acids 108-157 of Human Alcohol Dehydrogenase (NP_000658).
Applications
Application Notes
WB: 1 μg/ml; Peptide ELISA: 1/12500;
Target
Alternative Names
ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide; ADH1; alcohol dehydrogenase 1A; ADH, alpha subunit; aldehyde reductase; alcohol dehydrogenase subunit alpha; alcohol dehydrogenase 1 (class I), alpha polypeptide;
Product Background
Antigen Description
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.
Pathway
Abacavir metabolism; Biological oxidations; Chemical carcinogenesis; Drug metabolism - cytochrome P450
Citations
Publication ()
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COA
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