Genetic immunisation with cDNA encoding human PAP (PAcP, ACPP). Selection based on recognition of the complete native protein expressed on transfected mammalian cells.
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway.
Q: Can you clarify the species reactivity of the Anti-ACPP monoclonal antibody, clone MU4E2 ?
A: Anti-ACPP monoclonal antibody, clone MU4E2 are typically raised against Human ACPP antigens.
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