Specifications
Immunogen
A synthetic peptide corresponding to human ABCC1. The sequence is C-HQSDLKVDENQKAYY
Target
Alternative Names
ABCC1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; MRP; ABCC; GS-X; MRP1; ABC29; multidrug resistance-associated protein 1; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding
Product Background
Antigen Description
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
Pathway
ABC transporters; Arachidonic acid metabolism; Defective AMN causes hereditary megaloblastic anemia 1; Defective CD320 causes methylmalonic aciduria
Citations
Publication ()
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COA
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