Specifications
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human MRP1 aa 1500 to the C-terminus. The exact sequence is proprietary.Database link: P33527
Applications
Application Notes
Flow Cyt: 1/10; WB: 1/1000 - 1/10000.
Target
Alternative Names
ABCC1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; MRP, MRP1, multidrug resistance associated protein 1; multidrug resistance-associated protein 1; GS X; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter varian
Product Background
Antigen Description
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Pathway
ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; ABC-family proteins mediated transport, organism-specific biosystem; Irinotecan Pathway, organism-specific biosystem; Leukotriene synthesis, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem.
Citations
Publication ()
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COA
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